By G. E. Blair, M. E. Blair-Zajdel (auth.), Professor Dr. Walter Doerfler, Petra Böhm (eds.)
After 3 volumes on adenoviruses in 1995 the earlier years have obvious swift growth within the box of adenovirus learn. furthermore, adenoviruses have attracted substantial curiosity as vectors in gene move regimens. After the 1st quantity on virion and constitution, viral replication and host-cell interplay this moment quantity bargains with the immune procedure, oncogenesis and gene remedy.
Read or Download Adenoviruses: Model and Vectors in Virus-Host Interactions: Immune System, Oncogenesis, Gene Therapy PDF
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Extra info for Adenoviruses: Model and Vectors in Virus-Host Interactions: Immune System, Oncogenesis, Gene Therapy
2001). Most newly synthesized proteins will leave the ER at defined, COOH-terminus, cytoplasm KKXX, KXKXX XXRR Charged, hydrophilic aa DXE FF Short TMD of about -17 aa GRIP domain ER ER ER ER ER Goigi Goigi For abbreviations and details see text. C-terminus of peripheral Goigi proteins COOH-terminus, cytoplasm TMD COOH-terminus, cytoplasm TMD N-terminus, cytoplasm COOH-terminus, lumenal KDEL ER Location in protein Signal Compo Table 1 ER/Golgi sorting signals Golgin-245, golgin-97 Glycosyl- transferases, t-SNARES p24, ERGIC-53 VSV G protein Localization to certain membrane regions or aggregation Peripheral association with the Goigi ER export ER export ER retention (degradation) Barr 1999; Kjer-Nielsen et al.
From early endosomes, three trafficking routes are possible: (1) Recycling to the cell surface, (2) recycling to the TGN involving clathrin-coated vesicles and the clathrin adaptors AP-l and PACS-l, (3) transport to late endosomes requiring COPl subunits. From late endosomes, proteins are either delivered to lysosomes (Lys) to be degraded or to fulfill their function as lysosomal residents, or they are recycled to the TGN. The latter pathway seems to involve TIP47. For details and references see text grade pathway independent of COP I (Klumperman 2000).
After disassembly of the capsid, the DNA genome and associated proteins are imported into the nucleus, where early gene transcription starts (Russell 2000; Whittaker et al. 2000). The early Ad proteins induce cell-cycle progression without triggering the intrinsic apoptosis pathways, prepare the cell for DNA replication, and provide multiple protective measures against the attack by the immune system. In the late phase of infection, mainly structural proteins are being synthesized, and new virions are assembled in the nucleus.