Advances in Nuclear Oncology:: Diagnosis and Therapy by Emilio Bombardieri, John Buscombe, Giovanni Lucignani, Otmar

By Emilio Bombardieri, John Buscombe, Giovanni Lucignani, Otmar Schober

The diagnostic and healing achievements in radiopharmaceuticals and nuclear medication instrumentation ? puppy, SPECT, MR, CT and their hypbrids PET-CT and SPECT-CT

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Role of angiogenesis in tumor growth and metastasis. Semin Oncol 2002; 29 (6 Suppl 16): 15–18. 16. Abramovitch R, Dafni H, Smouha E, Benjamin LE, Neeman M. In vivo prediction of vascular susceptibility to vascular susceptibility endothelial growth factor withdrawal: magnetic resonance imaging of C6 rat glioma in nude mice. Cancer Res 1999; 59: 5012–16. 17. Cavallaro U, Liebner S, Dejana E. Endothelial cadherins and tumor angiogenesis. Exp Cell Res 2006; 312: 659–67. 18. Baluk P, Hashizume H, McDonald DM.

J Nucl Med 2004; 45: 1851–9. 24. Chen X, Park R, Shahinian AH et al. 18F-labeled RGD peptide: initial evaluation for imaging brain tumor angiogenesis. Nucl Med Biol 2004; 31: 179–89. 25. Pasqualini R, Koivunen E, Ruoslahti E. Alpha v integrins as receptors for tumor targeting by circulating ligands. Nat Biotechnol 1997; 15: 542–6. 26. Blasberg RG, Roelcke U, Weinreich R et al. Imaging brain tumor proliferative activity with [124I]iododeoxyuridine. Cancer Res 2000; 60: 624–35. 27. Carnochan P, Brooks R.

G. the aromatase inhibitor letrozole14). However, the response to target specific treatment regimens can be difficult to predict, which spurs the development of new target specific imaging probes that may help to enhance the clinical risk stratification due to improved diagnostic capabilities, optimize therapy based on molecular target characterization, and improve efficacy assessments. Generally speaking, fundamental biological properties of oncological processes that are desirable to measure by means of molecular imaging include angiogenesis, proliferation, apoptosis, and hypoxia; these will be briefly reviewed hereafter.

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