Advances in spinal fusion: molecular science, biomechanics, by Kai-Uwe Lewandrowski

By Kai-Uwe Lewandrowski

Showcasing rising learn and expertise within the box, Lewandrowski (fellow, spinal surgical procedure, Cleveland health facility) offers descriptions of a brand new new release of fabrics and units in a position to particular organic interactions to augment spinal fusion, from biodegradable implants and advances in drug supply to recombinant DNA recommendations, bioreactors, stem mobilephone isolation, and second and 3D scaffolds for cells. The e-book offers with matters within the collection of right biomaterials that handle biocompatibility and biostability, particular biomaterials and their physiochemical and mechanical characterizations. concerns relating to criteria in analytical technique and qc also are mentioned. members come from fields starting from the elemental sciences, equivalent to polymer chemistry, to extra utilized disciplines, corresponding to chemical engineering, orthopedics, and pharmaceutics. B&w drawings and scientific photos are incorporated.

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Extra info for Advances in spinal fusion: molecular science, biomechanics, and clinical management

Sample text

B. Height Restoration Restoring height to collapsed VBs is of interest clinically because it has the potential benefit of reducing postfracture kyphosis and its associated sequelae [26,52–55]. A new device, the inflatable bone tamp, has been developed as a means of restoring height [56,57]. This tamp is placed inside the VB under fluoroscopic guidance via a percutaneously introduced cannula and inflated to create a void into which bone cement may be injected to stabilize the VB. In the process of inflating the tamp, the endplates are separated from each other, thereby reducing the fracture.

The spinal, or Jamshidi, needle is then inserted. It should be angled approximately 10 degrees toward the midline in the thoracic and lumbar spine. In the lower lumbar spine, particularly at L5, more medial orientation may be needed. The needle should be advanced into the bone about 2–3 mm. The location is then checked on both radiographic views to confirm proper orientation. The Jamshidi needle is slowly advanced with a gentle twisting motion. Tactile feedback should help guide the instrument within bone.

Concerns have been raised that PV hypothetically creates a stress concentration, alters spine kinematics, and places adjacent levels at risk of fracture. This concern seems unfounded for several reasons. First, PV appears to restore, or nearly restores, stiffness and does not increase stiffness relative to prefracture levels [43–47]. Thus, adjacent levels should be at no greater risk than they were in the prefracture state. Even if the VB stiffness were increased relative the prefracture state, the stiffness of an individual level is unlikely to affect spinal kinematics.

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