Apoptosis and Cancer Chemotherapy by J. Martin Brown PhD, Bradly G. Wouters PhD (auth.), John A.

By J. Martin Brown PhD, Bradly G. Wouters PhD (auth.), John A. Hickman, Caroline Dive (eds.)

The prior few years have witnessed an impressive overseas attempt that tested the position of a few 20 new molecules in apoptosis and further activation or suppression of apoptosis to the accredited organic services of a superb many others already time-honored in melanoma biology. a few of these molecules are receptors, transducing cytokine-mediated indications; others seem to accentuate or reduce the danger compro­ mised phone will fireplace its apoptosis effector mechanism. All are of curiosity as power objectives for tumor treatment, and a few may perhaps end up to be keep watch over issues inspired within the pathogenesis of melanoma and different ailments as various as viral an infection, neurodegenerative issues, and stroke. occasionally, in the middle of those advancements, one of those euphoria ap­ pears to have gripped the examine group, with the expectancy that apoptosis will have the funds for factors to many unsolved questions in cellu­ lar rules. This ebook, in a chain of considerate and provocative ar­ ticles--some from demonstrated leaders within the box, and others from more youthful scientists--seeks to redress the balance.

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31. Zolzer F, Hillebrandt S, Streffer C. Radiation induced G I-block and p53 status in six human cell lines. Radiother Onco11995; 37: 20-28. 32. Biard DS, Martin M, Rhun YL, Duthu A, Lefaix JL, May E, May P. Concomitant p53 gene mutation and increased radiosensitivity in rat lung embryo epithelial cells during neoplastic development. Cancer Res 1994; 54: 3361-3364. 33. Servomaa K, Kiuru A, Grenman R, Pekkola-Heino K, Pulkkinen JO, Rytomaa T. p53 mutations associated with increased sensitivity to ionizing radiation in human head and neck cancer cell lines.

Servomaa K, Kiuru A, Grenman R, Pekkola-Heino K, Pulkkinen JO, Rytomaa T. p53 mutations associated with increased sensitivity to ionizing radiation in human head and neck cancer cell lines. Cell Prolif 1996; 29: 219-230. 34. Pardo FS, Su M, Borek C, Preffer F, Dombkowski D, Gerweck L, Schmidt EY. Transfection of rat embryo cells with mutant p53 increases the intrinsic radiation resistance. Radiat Res 1994; 140: 180-185. 35. Gupta N, Vij R, Haas-Kogan DA, Israel MA, Deen DF, Morgan WE Cytogenetic damage and the radiation-induced G I-phase checkpoint.

Int J Cancer 1998; 75: 933-940. 22. Roth JA. Gene replacement strategies for lung cancer. Curr Opin Onco11998; 10: 127-312. -23. Ju JF, BaneIjee D, Lenz HJ, Danenberg KD, Schmittgen TC, Spears CP, et al. Restoration of wild-type p53 activity in p53-null HL-60 cells confers multidrug sensitivity. Clin Cancer Res 1998; 4: 1315-1322. -24. Gjerset RA, Turla ST, Sobol RE, Scalise JJ, Mercola D, Collins H, Hopkins P1. Use of wild-type p53 to achieve complete treatment sensitization of tumor cells expressing endogenous mutant p53.

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