Applications of Domino Transformations in Organic Synthesis, by Scott A. Snyder, Erick M. Carreira, Carl P. Decicco, Alois

By Scott A. Snyder, Erick M. Carreira, Carl P. Decicco, Alois Fürstner, Guido Koch, Gary A. Molander, Ernst Schaumann

The swift speed of evolution in domino, or cascade-based adjustments has revolutionized the perform of chemical synthesis for the production of ordinary items, designed molecules, and pharmaceuticals.


"Science of Synthesis: purposes of Domino changes in natural Synthesis" explores the subject completely and systematically, serving because the foundation for functional purposes and destiny examine. The 2-volume set provides the state-of-the-art by way of layout, approach, and experimental approaches, resulting in a number of occasions being entire inside of a unmarried response vessel. The content material is geared up by way of the center form of response used to start up the development, be it a pericyclic response, a metal-mediated transformation, radical chemistry, or an acid-induced cascade between many others.


Volume 1 covers polyene/cation-pi cyclizations, metathesis, radical, and metal-mediated reactions, and non-radical skeletal rearrangements.

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Extra info for Applications of Domino Transformations in Organic Synthesis, Volume 1

Sample text

1 Domino Reactions with Transition-Metal Catalysts . . . . . . . . . . . . . 5 Cobalt and Other Metal Mediated Domino Reactions: The Pauson–Khand Reaction and Its Use in Natural Product Total Synthesis L. Shi and Z. 1 Enyne-Based Pauson–Khand Reactions . . . . . . . . . . . . . . . . . . . 1 A Short Synthesis of Racemic 13-Deoxyserratine . . . . . . . . . . . . . . 2 Total Synthesis of Paecilomycine A . . . . . . . . . . . . .

1 1,4-Brook Rearrangement of Silyl-Substituted Carbanions with Epoxides . . . 2 1,4-Brook Rearrangement with Dihalosilyl-Substituted Methyllithium . . . . 3 1,4-Brook Rearrangement with Allylsilanes . . . . . . . . . . . . . . . . . 4 1,4-Brook Rearrangement with Silylated Benzaldehydes . . . . . . . . . . 5 1,4-Brook Rearrangement with Vinylsilanes . . . . . . . . . . . . . . . . 6 Sulfur to Oxygen Rearrangement .

633 Author Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 669 Abbreviations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 693 1 Introduction S. A. Snyder There is something inherently satisfying about setting up a number of dominoes in series, pushing one down at the end of the chain, and watching the rest tumble as if in slow motion until all have been knocked over; I remember spending hours doing this as a child, once my father showed me the principle and I had enough dexterity to not knock anything down before the right moment.

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